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The conundrum about this popular drug’s full mechanism of action is unusual compared to  shirt aew sting .Two hypotheses exist to explain Wellbutrin’s disproportionate effects. The first is that its metabolites and the resulting neurotransmitter release augment the prodrug’s actions. The second is that this drug achieves and only requires limited occupancy in binding (or docking) to targeted dopamine receptors. (Higher occupancy might cause dopamine-induced euphoric reward.) This inhibition of dopamine is similar to the second-generation antipsychotics that only “ring the bell” of targeted dopamine—meaning only partial occupancy and a shorter binding time compared to first-generation antipsychotics which occupy 95% of these D2 receptors nearly 24 hours/day in all five dopamine pathways causing extrapyramidal symptoms, tardive dyskinesia and sometimes neuroleptic symptoms. In contrast to Wellbutrin, SRI (formerly SSRI) and SNRI anti-

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-depressants occupy every serotonin receptors in every pathway at a level of 90–95% giving rise to  shirt aew sting  The way doctors deal this is by prescribing Wellbutrin which resolves the sexual symptoms (one such combination of Zoloft and Wellbutrin is referred to as “Welloft.” But this raises the issue of why not simply prescribe Wellbutrin—which has global status as a first-line monotherapy in and of itself. If the doctor determines the need for serotonin, he must add an SRI because Wellbutrin has zero effect on this neurotransmitter.